KR20070085220A Production of polypeptides 

KR20070085220A Production of polypeptides

  • US20190040435A1 - Decreasing lactate level and increasing ...

    The present invention provides methods and compositions for reducing lactate production and increasing polypeptide production in cultured cells. In one aspect, the invention provides a method comprising culturing cells expressing a) a small interfering RNA (siRNA) specific for a lactate dehydrogenase (LDH) and b) an siRNA specific for a pyruvate dehydrogenase kinase (PDHK).

    Cited by 28

    Get Price

  • US7294484B2 - Production of polypeptides - Google Patents

    An improved system for large scale production of proteins and/or polypeptides in cell culture, particularly in media characterized by one or more of i) a cumulative amino acid concentration greater than about 70 mM; ii) a molar cumulative glutamine to cumulative asparagine ratio of less than about 2; iii) a molar cumulative glutamine to cumulative total amino acid ratio of less than about 0.2 ...

    Cited by 114

    Get Price

  • US20190040435A1 - Decreasing lactate level and increasing ...

    The present invention provides methods and compositions for reducing lactate production and increasing polypeptide production in cultured cells. In one aspect, the invention provides a method comprising culturing cells expressing a) a small interfering RNA (siRNA) specific for a lactate dehydrogenase (LDH) and b) an siRNA specific for a pyruvate dehydrogenase kinase (PDHK).

    Get Price

  • US7294484B2 - Production of polypeptides - Google Patents

    An improved system for large scale production of proteins and/or polypeptides in cell culture, particularly in media characterized by one or more of i) a cumulative amino acid concentration greater than about 70 mM; ii) a molar cumulative glutamine to cumulative asparagine ratio of less than about 2; iii) a molar cumulative glutamine to cumulative total amino acid ratio of less than about 0.2 ...

    Get Price

Contact
+86-21-61902951 [email protected] 0086-21-61902951 24 Hours Online! Chat Us Freely!